The Bottle’s Blue, Not You. Answering Common Questions About Argyria.

What is argyria?

One main concern that individuals may have with silver products is a rare skin condition known as argyria, otherwise known as “the blue man syndrome”. Put simply, argyria is a result of there being so much chemical or ionic silver in the body at one time that the body cannot dispose of it fast enough through its normal excretion systems. In order to get rid of this excess silver, the body walls it off in the cells. This causes a grayish blue discoloration of the skin and other body tissues. Although this condition is medically benign and cosmetic only, in most cases the discoloration is permanent.

What causes argyria and what doesn’t?

Understanding the obvious fears individuals may have with acquiring argyria, let us settle your concerns with simple, clear and proven facts. To start, we’ll begin with research gathered from the Environmental Protection Agency (EPA). According to the EPA (who is in charge of defining safe levels of any mineral in water which is used for ingestion, drinking, or disinfecting), the oral consumption of the equivalence of 1oz of 10ppm of silver in water on a daily basis poses no significant degree of risk.

According to historical information published on silver, unless an individual were consistently consuming (every day for over a year) over 50 times the recommended daily dosage of a 10 ppm ionic silver product, there would be no possibility of that individual contracting argyria. That is the equivalent of drinking 380 – 8 oz. bottles of a 10 ppm ionic silver product in one year, which is more than a bottle a day!  So, those people who consume hundreds or even thousands of times the recommended daily dosages do run a risk of developing this condition over time.  Argyria is generally only a potential problem for people who make their own ionic silver products at home with no idea of the levels of silver they are ingesting, or from the daily use of commercially available ionic silver products at 200-500 ppm or even higher.

How do we know metallic silver doesn’t cause argyria?

A peer-reviewed report from Pennsylvania State University was released after years of studying a number of colloidal silver and silver aquasol or nano products purchased from the U.S. market. The paper was authored by Professor Rustum Roy, along with seven other professors and scientists from leading universities. In the report cited below, on the subject of ionic vs. metallic silver for human use, Dr. Roy states “In spite of this enormous range of data, it is extraordinary that no major effort has been made to confirm and expand on the role of metallic silver in human health—especially in light of its huge advantage in lack of side effects”. (Ingestion of excessive amounts of ionic (soluble) silver, not metallic solid particles is reported to have resulted in a very rare condition labeled argyria, an (irreversible?) darkening of the skin. No one has died of this condition. The safety of metallic SilverSols® is firmly established by the data cited above).” 1

That paper also states that “For thousands of years in various countries, especially India, silver has been used for what was empirically known to be its bactericidal properties – to keep water, and often foods, safer.  A recent paper by Das et al. provides the remarkable datum that some 275,000 kg of edible metallic silver foil are consumed every year (in food) in India.  No known adverse health effects have ever been recorded.  This epidemiological evidence that silver as a metal is not toxic in any way needs no further comment.”1

To put that simply, metallic silver products like our SilverSol Technology® do not cause argyria.  It is only ionic forms of silver that cause argyria.

How do we know that SilverSol® is safe?

On top of the safety information listed above, the SilverSol Technology® in our Silver Biotics® products has undergone more than 30 safety studies, including the first human ingestion safety studies done on a nano-silver.  These safety studies have shown that the metallic nano-silver particles in SilverSol are flushed out of the body within approximately 24 hours.  No build-up or retention of the SilverSol particles occurs in the body, which means it is scientifically impossible to get argyria from SilverSol® at the recommended dosage.  We have also sold millions of bottles of our products over the last 20 years, with no reported negative side effects.  This is why we can confidently say that our bottles are blue, but not you.


Roy et al. Ultradilute Ag-aquasols with extraordinary bactericidal properties: role of the system Ag-0-H20. Materials Research Innovations, 2007, Vol 11, No 1.